The in vitro assays provide valuable data for deciphering the mechanisms and drug-related determinants underlying the drug candidates’ journey in the body and predicting the in vivo pharmacokinetic (PK) and pharmacodynamics (PD) profiles.
in vivo pharmacokinetic assays (in rodents)
In vivo PK studies, compounds are administered to rodents and samples collected over a pre-defined time period. The dosing regimen and sampling are designed according to the project needs and prior information available on the study compounds.
Services
• Single or repeated dosing (i.p., i.v., p.o., s.c., i.m.); • Studies with small molecules, peptides and proteins; • Plasma sampling, tissue and CSF collection; • Bioanalysis by LC/MS/MS or UPLC/High-resolution-MS analysis.
