• The same recommendations relevant to sub-acute dose toxicology; • 90-days studies provides information on the possible health hazards likely to arise from repeated exposure over a prolonged period of time; • The study will provide information on the major toxic effects, indicate target organs and the possibility of accumulation of test chemical, and can provide an estimate of NOAEL; • This study provides dose response related data that may be used to estimate point of departure for hazard assessment using appropriate modelling methods.