The same recommendations relevant to sub-acute dose toxicology
90-days studies provides information on the possible health hazards likely to arise from repeated exposure over a prolonged period of time
The study will provide information on the major toxic effects, indicate target organs and the possibility of accumulation of test chemical, and can provide an estimate of NOAEL
This study provides dose response related data that may be used to estimate point of departure for hazard assessment using appropriate modelling methods

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Clinical Signs (morbidity and mortality)
Food consumption; body weight
Clinical Examination – tumors, distended abdomen, kyphosis, etc
Ophthalmologic examination – cataracts, eye discharge, corneal opacity, etc
Functional Observational Battery (FOB) – tail stiffening, forelimb grip strength, body temperature, etc
Neuronal Observational Battery (NOB) – gait disorders, tremor, menace reflex
Necropsy
Organ Weight
Hematology and Clinical Biochemistry
Histopathology

SUB-CHRONIC TOXICOLOGY