Purpose

• To identify substances that can cause genetic alterations in somatic and/or germ cells
• Genetic alterations may result in effects manifested after very long periods of time
• Genetic alterations in somatic cells may cause cancer or other genetic diseases
• Accumulation of DNA damage can also be related to neurodegenerative diseases
• In germ cells, DNA damage is associated with spontaneous abortions, infertility or heritable damage
• To adequately cover all genetic endpoints, various tests may be required