ACUTE TOXICOLOGY

The current view is that adequate information on acute toxicity can be obtained from other sources than specific single-dose toxicity
“Extended” single-dose toxicity studies evaluate hematology, clinical chemistry, necropsy and histopathology

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Clinical Signs (morbidity and mortality)
Detailed clinical examination at least twice on the day of exposure (this includes changes in skin and fur, eyes, breathing rate, somatomotor activity and behavior
Necropsy
Organ Weight
Fixation