CANDIDATE

IN VIVO EFFICACY AND TOXICITY TESTS IN RODENT AND COMPANION ANIMAL MODELS

Vision Sciences

Mouse and rat models

Diabetic retinopathy
Rat model of prediabetes (administration of high concentration of sucrose in water)
Mice and rat model of type 1 diabetes by intraperitoneal injection of streptozotocin
Mouse model of type I diabetes (Ins2Akita)

Glaucoma
Ocular hypertension induced by microbeads injection
DBA/2J mouse
Induced by Episcleral vein coagulation

Age-related macular degeneration (AMD)
Light-induced retinal damage (dry AMD)

Models of retinal injury
Transient retinal ischemia-reperfusion (I-R)
Excitotoxicity-induced retinal degeneration model (intravitreal injection of excitotoxic drugs, such as glutamate)
Ocular inflammation model (injection of LPS)

 

Rabbits

Companion animals
Assays and Techniques:
Intraocular pressure (IOP) measurement (Tonolab)
Optical coherence tomography (OCT)
Electroretinography (ERG)
Pattern electroretinography (pERG)
Scotopic threshold response (STR)
Visual-evoked potentials (VEP)
Optomotor response (OMR)
Fluorescein angiography
Biomicroscopy
Fundoscopy
Intravitreal microinjection of proteins for assessment of crossover of hematoocular barriers

 

Oncology

 
Goal: monitoring tumour progression and treatment response in preclinical studies
Model: bioluminescent canine B-cell lymphoma xenograft model